| Title | Released | Developer | Publisher | 
| Santa Claus in Trouble | 2002 | Joymania | CDV | 
| S.C.A.R.S. | 1998 | Vivid Image | Ubisoft | 
| S.T.A.L.K.E.R.: Call of Pripyat | 2009 | GSC Game World |  | 
| S.T.A.L.K.E.R.: Clear Sky | 2008 | GSC Game World | GSC World Publishing | 
| S.T.A.L.K.E.R.: Shadow of Chernobyl | 2007 | GSC Game World | THQ | 
| S4 League | 2008 | Pentavision | Neowiz Games | 
| The Saboteur | 2009 | Pandemic Studios | Electronic Arts | 
| Sacred | 2004 | Ascaron | Encore Games | 
| Sacrifice | 2000 | Shiny Entertainment | Interplay Entertainment | 
| Safecracker: The Ultimate Puzzle Adventure | 2006 | Kheops Studio | The Adventure Company | 
| The Saga of Ryzom | 2004 | Winch Gate | Winch Gate | 
| The Sagara Family | 2003 | ZyX | ZyX, G-Collections | 
| Saints Row 2 | 2008 | Volition, Inc. | THQ | 
| Sakura Sakura | 2009 | Haikuo Soft | Haikuo Soft | 
| Sakura Spirit | 2014 | Winged Cloud | Sekai Project | 
| Sakura Strasse | 2008 | Palette | Palette | 
| Salammbo: Battle for Carthage | 2003 | Cryo Interactive | Cryo Interactive | 
| Salt Lake 2002 | 2002 | Attention To Detail | Eidos Interactive | 
| Sam & Max Beyond Time and Space | 2007 | Telltale Games | Telltale Games | 
| Sam & Max Hit the Road | 2002 | LucasArts | LucasArts | 
| Sam & Max Save the World | 2006 | Telltale Games | The Adventure Company, JoWood Productions | 
| Sammy's Science House | 1994 | Theatrix Interactive | Edmark | 
| Samurai Shodown II | 1996 | SNK | SNK | 
| Samurai Warriors 2 | 2006 | Koei, Omega Force | Koei | 
| Samurai Gunn | 2013 | Teknopants | Maxistentialism | 
| Sangokushi Koumeiden | 1996 | Koei | Koei | 
| Sangokushi Sousouden | 1998 | Koei |  | 
| Sanitarium | 1998 | DreamForge Intertainment | ASC Games, XS Games, LLC | 
| Sanity: Aiken's Artifact | 2000 | Monolith Productions | Fox Interactive | 
| Santa's Secret Valley | 1995 | AHA! Software | AHA! Software | 
| Savage 2: A Tortured Soul | 2008 | S2 Games | S2 Games | 
| Savage Skies | 2002 | iRock Interactive | BAM! Entertainment | 
| Savage: The Battle for Newerth | 2003 | S2 Games | iGames, TriSynergy | 
| Saw | 2009 | Zombie Studios | Konami | 
| Saya no Uta | 2003 | Nitroplus | Nitroplus | 
| Scan Command: Jurassic Park | 2001 | Knowledge Adventure | Knowledge Adventure | 
| Scarface: The World Is Yours | 2006 | Radical Entertainment | Sierra Entertainment | 
| Scarlet Weather Rhapsody | 2008 | Twilight Frontier | Twilight Frontier | 
| Schizm: Mysterious Journey | 2001 | LK Avalon | LK Avalon, The Adventure Company | 
| School Tycoon | 2004 | Cat Daddy Games | Global Star Software | 
| Scivelation | 2009 | Black Wing Foundation |  | 
| Scooby-Doo! Mystery of the Fun Park Phantom | 1999 | Engineering Animation, Inc. | SouthPeak Interactive | 
| Scorched 3D | 2001 | Gavin Camp |  | 
| Scorcher | 1996 | Zyrinx | Scavenger, Inc. | 
| Scrapland | 2004 | Mercury Steam Entertainment | Enlight | 
| Scratches | 2006 | Nucleosys | Got Game Entertainment | 
| Screamer 4x4 | 2001 | Clever's Development | Virgin Interactive | 
| Screamer Rally | 1997 | Milestone S.r.l. | Virgin Interactive | 
| Screencheat | 2014 | Samurai Punk | Surprise Attack | 
| Sea Dogs | 2000 | Akella | Bethesda Softworks | 
| Sea Life Safari | 2007 | Wild Tangent | Sierra On-Line | 
| Search and Destroy | 1992 | Randy Baron | Randy Baron | 
| Season of the Sakura | 2002 | JAST | JAST, JAST USA | 
| SeaWorld Adventure Parks Tycoon | 2003 | Deep Red Games | Activision | 
| Second Face, AA Second Face | 2008 | Jospin Le Woltaire |  | 
| Second Sight | 2004 | Free Radical Design | Codemasters | 
| Secret Files 2: Puritas Cordis | 2009 | Fusionsphere Systems | Deep Silver | 
| Secret Files: Tunguska | 2006 | Fusionsphere Systems | Dreamcatcher Interactive, The Adventure Company, Deep Silver | 
| Secret Maryo Chronicles | 2003 | SMC Development Team |  | 
| The Secret of Monkey Island: Special Edition | 2009 | LucasArts | LucasArts | 
| The Secret of Shadow Ranch | 2004 | Her Interactive | DreamCatcher | 
| The Secret of the Nautilus | 2001 | Cryo Interactive | Cryo Interactive | 
| Secret of the Old Clock | 2005 | Her Interactive | DreamCatcher | 
| Secret of the Scarlet Hand | 2002 | Her Interactive | DreamCatcher | 
| Secret of the Solstice | 2007 | DNC Entertainment | DNC Entertainment, Outspark | 
| Secret Paths in the Forest | 1997 | Purple Moon | Purple Moon | 
| Secret Service | 2008 | Cauldron HQ | Activision Value | 
| Secret Service | 2001 | Fun Labs | Activision Value | 
| Secret Service 2 | 2003 | 4D Rulers | Activision Value | 
| Secret Weapons Over Normandy | 2003 | Totally Games | LucasArts | 
| Secret Wives' Club | 2002 | Sekilala | Sekilala, G-Collections | 
| Secrets Can Kill | 1998 | Her Interactive | DreamCatcher Games | 
| The Secrets of Atlantis: The Sacred Legacy | 2007 | The Adventure Company | Dreamcatcher Interactive | 
| Section 8 | 2009 | TimeGate Studios | SouthPeak Interactive | 
| Seed | 2006 | Runestone Game Development | Runestone Game Development | 
| Sega Bass Fishing | 2001 | Sega | Sega | 
| Sega GT | 2001 | Wow Entertainment | Sega Corporation, Sega PC | 
| Sega Marine Fishing | 2001 | Wow Entertainment, Inc. | Sega, Empire Interactive Europe Ltd. | 
| Sega Rally 2 | 1998 | AM5 | Sega | 
| Sega Rally Championship | 1995 | AM5 | Sega | 
| Sega Rally Revo | 2007 | SEGA Racing Studio | Sega | 
| Sega Smash Pack | 1999 | Sega | Sega | 
| Sega Smash Pack 2 | 2000 Sega | Sega | 
| Sega Touring Car Championship | 1996 | Sega-AM3 | Sega | 
| Sega Worldwide Soccer '97 | 1996 | Sega | Sega | 
| Sensible Golf | 1995 | Sensible Software | Virgin Interactive | 
| Sensible Soccer 98 | 1998 | Sensible Software | GT Interactive | 
| Sensible Soccer '98: European Club Edition | 1999 | Sensible Software | GT Interactive | 
| Sensible Soccer 2006 | 2006 | Kuju Sheffield | Codemasters | 
| Sentient | 1997 | Psygnosis | Psygnosis | 
| Sentinel Returns | 1998 | Hookstone | Psygnosis | 
| Septerra Core: Legacy of the Creator | 1999 | Valkyrie Studios | Monolith Productions | 
| Serious Sam | 2001 | Croteam | Gathering of Developers | 
| Serious Sam II | 2005 | Croteam | 2K Games | 
| The Settlers II (Gold Edition) | 1997 | Blue Byte | Blue Byte | 
| The Settlers II: 10th Anniversary | 2006 | Blue Byte | Ubisoft | 
| The Settlers III | 1998 | Blue Byte | Focus Multimedia Ltd. | 
| The Settlers III: Quest of the Amazons | 1999 | Blue Byte | Blue Byte | 
| The Settlers IV | 2001 | Blue Byte | Blue Byte | 
| The Settlers: Heritage of Kings | 2005 | Blue Byte | Ubisoft | 
| The Settlers: Rise of an Empire | 2007 | Blue Byte | Ubisoft | 
| Settlers 7: Paths to a Kingdom | 2010 | Blue Byte | Ubisoft | 
| Seven Kingdoms II: The Fryhtan Wars | 1999 | Enlight | Ubisoft | 
| Severance: Blade of Darkness | 2001 | Rebel Act Studios | Codemasters | 
| Shadow Man | 1999 | Acclaim Studios Teesside | Acclaim Entertainment, Gradiente | 
| Shadow of Memories | 2001 | Konami | Konami | 
| Shadow Ops: Red Mercury | 2004 | Zombie Studios | Atari | 
| Shadowbane | 2003 | Wolfpack Studios, Stray Bullet Games | Ubisoft | 
| Shadowgate | 1993 | ICOM Simulations, Inc. | Viacom New Media | 
| Shadowgrounds | 2005 | Frozenbyte | Plan 1, Meridian4 | 
| Shadowgrounds Survivor | 2007 | Frozenbyte | Frozenbyte | 
| Shadowrun | 2007 | FASA Interactive | Microsoft Game Studios | 
| Shadows of Cairn | 1994 | Ant Software | Masque Publishing | 
| Shaiya | 2007 | Sonovaslag Entertainment | Aeria Games, Entertainment,Inc. | 
| Shanghai II: Dragon's Eye | 1994 | Activision | Activision | 
| Shannara | 1995 | Legend Entertainment | Legend Entertainment | 
| Shank | 2010 | Klei Entertainment | Electronic Arts | 
| Shaq-Fu: A Legend Reborn | 2015 | Big Deez Productions | Big Deez Productions | 
| Sharin no Kuni, Himawari no Shōjo | 2005 | Akabeisoft2 | Akabeisoft2 | 
| Shark Tale | 2004 | Edge of Reality | Activision | 
| Shattered Horizon | 2009 | Futuremark Games Studio | Futuremark Games Studio | 
| Shattered Union | 2005 | PopTop Software | 2K Games | 
| Shaun White Snowboarding | 2008 | Ubisoft Montreal | Ubisoft | 
| Sheep | 2000 | Mind's Eye Productions | Empire Interactive | 
| Sheep, Dog 'n' Wolf | 2001 | Infogrames | Infogrames | 
| Shellshock 2: Blood Trails | 2009 | Rebellion Developments | Eidos Interactive | 
| Shellshock: Nam '67 | 2004 | Guerrilla Games | Eidos Interactive | 
| Sherlock Alavi | 2009 | Amir hoshang Emamjomeh, Ali Emamjomeh | Andishe varan | 
| Sherlock Holmes versus Arsène Lupin | 2007 | Frogwares | Focus Home Interactive | 
| Sherlock Holmes Versus Jack the Ripper | 2009 | Frogwares | Focus Home Interactive | 
| Sherlock Holmes: The Mystery of the Mummy | 2002 | Frogwares | The Adventure Company | 
| Sherlock Holmes: The Case of the Silver Earring | 2004 | Frogwares | Ubisoft | 
| Sherlock Holmes: The Awakened | 2006 | Frogwares | Focus Home Interactive | 
| The Shield | 2007 | Point of View, Inc. | Aspyr Media | 
| Shikkoku no Sharnoth: What a Beautiful Tomorrow | 2008 | Liar-soft | Liar-soft | 
| Shin Megami Tensei: Imagine | 2007 | Cave | Atlus, Aeria, Playsea | 
| Ship Simulator | 2006 | VSTEP | Lighthouse Interactive | 
| The Ship | 2006 | Outerlight | Valve Corporation, Mindscape Group, Merscom | 
| Shivers | 1995 | Sierra On-Line | Sierra On-Line | 
| Shivers II: Harvest of Souls | 1997 | Sierra On-Line | Sierra On-Line | 
| Shizuku | 1996 | Leaf | Aquaplus | 
| Shockwave Assault | 1995 | Crystal Dynamics | Crystal Dynamics, Electronic Arts | 
| Shogo: Mobile Armor Division | 1998 | Monolith Productions | Monolith Productions | 
| Shogun: Total War | 2000 | The Creative Assembly | Electronic Arts | 
| Shoot the Bullet | 2005 | Team Shanghai Alice | Team Shanghai Alice | 
| Shotest Shogi | 2008 | AI Factory, Rubicon Development | AI Factory, Rubicon Development | 
| Shrak | 1997 | Quantum Axcess | Quantum Axcess | 
| Shrek 2 | 2004 | Luxoflux, Amaze Entertainment | Activision | 
| Shrek SuperSlam | 2005 | 7 Studios | Activision, Shaba Games | 
| Shrek the Third | 2007 | 7 Studios, Shaba Games | Activision | 
| Sid Meier's Alien Crossfire | 1999 | Firaxis Games | Electronic Arts | 
| Sid Meier's Alpha Centauri | 1998 | Firaxis Games | Electronic Arts | 
| Sid Meier's Antietam! | 1998 | Firaxis Games | Electronic Arts | 
| Sid Meier's Colonization | 1994 | Microprose | Microprose | 
| Sid Meier's Gettysburg! | 1997 | Firaxis Games | Electronic Arts | 
| Sid Meier's Pirates! | 2004 | Firaxis Games | Atari, 2K Games, Valve Corporation | 
| Sid Meier's Railroads! | 2006 | Firaxis Games | 2K Games | 
| Sid Meier's SimGolf | 2002 | Maxis | Electronic Arts | 
| Silent Hill 2 | 2001 | Konami | Konami | 
| Silent Hill 3 | 2003 | Konami | Konami | 
| Silent Hill 4: The Room | 2004 | Konami | Konami | 
| Silent Hill Homecoming | 2008 | Konami Digital Entertainment, Double Helix Games | Konami Digital Entertainment | 
| Silent Hunter II | 2002 | Ultimation Inc. | Focus Multimedia Ltd. | 
| Silent Hunter III | 2005 | Ubisoft Romania | Ubisoft | 
| Silent Hunter 4: Wolves of the Pacific | 2007 | Ubisoft Romania | Ubisoft | 
| Silent Hunter 4: Wolves of the Pacific (Deluxe Edition) | 2007 | Ubisoft SRL | Ubisoft GmbH | 
| Silent Hunter 4: Wolves of the Pacific (Collector's Edition) | 2007 | Ubisoft SRL | Ubisoft Entertainment SA | 
| Silent Hunter: Wolves of the Pacific (Gold Edition) | 2008 | Ubisoft SRL | Ubisoft | 
| Silent Hunter 4: Wolves of the Pacific - U-Boat Missions | 2008 | Ubisoft SRL | Ubisoft Entertainment SA | 
| Silent Hunter 5: Battle of the Atlantic | 2010 | Ubisoft Romania | Ubisoft | 
| Silent Storm | 2003 | Nival Interactive | JoWood Productions | 
| SilentHeroes | 2003 | Team SH, Digital Software |  | 
| Silver | 1999 | Infogrames | Infogrames | 
| Silver Knights | 2002 | Haruo Teshima |  | 
| Silverfall | 2007 | Monte Cristo | Monte Cristo | 
| SimAnt | 1991 | Maxis | Maxis | 
| SimCity | 1992 | Maxis | Maxis | 
| SimCity 2000 | 1993 | Maxis | Maxis, Electronic Arts | 
| SimCity 3000 | 1999 | Maxis | EA Games | 
| SimCity 4 | 2003 | Maxis | Electronic Arts | 
| The SimCity Box | 2008 | Maxis | Electronic Arts | 
| SimCity Societies | 2007 | Tilted Mill Entertainment | Electronic Arts | 
| SimCity Societies: Destinations | 2008 | Tilted Mill Entertainment | Electronic Arts | 
| SimCopter | 1996 | Maxis | Electronic Arts | 
| SimEarth | 1990 | Maxis | Maxis | 
| SimFarm | 1993 | Maxis | Maxis, Mindscape | 
| SimGolf | 1996 | Maxis | Maxis | 
| SimIsle: Missions in the Rainforest | 1995 | Intelligent Games, Ltd. | Maxis | 
| SimLife | 1992 | Maxis | Maxis | 
| Simon the Sorcerer | 2002 | Adventure Soft | Adventure Soft | 
| Simon the Sorcerer II: The Lion, the Wizard and the Wardrobe | 1995 | Adventure Soft | Adventure Soft | 
| Simon the Sorcerer 3D | 2002 | Headfirst Productions | Adventure Soft | 
| Simon the Sorcerer 4: Chaos Happens | 2007 | Silver Style Entertainment | RTL Enterprises, Playlogic Entertainment | 
| Simon the Sorcerer's Pinball | 1998 | Adventure Soft | Adventure Soft | 
| Simon the Sorcerer's Puzzle Pack | 1998 | Adventure Soft | Adventure Soft | 
| SimPark | 1996 | Maxis | Maxis | 
| SimPort | 2007 | Tygron, Port of Rotterdam, TU Delft |  | 
| The Simpsons Cartoon Studio | 1996 | Big Top Productions | Fox Interactive | 
| The Simpsons: Virtual Springfield | 1997 | Digital Evolution | Fox Interactive | 
| The Sims 2 | 2004 | Maxis | Electronic Arts | 
| The Sims 2: Apartment Life | 2008 | The Sims Division | Electronic Arts | 
| The Sims 2: Bon Voyage | 2007 | The Sims Division | Electronic Arts | 
| The Sims 2: FreeTime | 2008 | The Sims Division | Electronic Arts | 
| The Sims 2: Nightlife | 2005 | Maxis | EA Games | 
| The Sims 2: Open for Business | 2006 | Maxis | EA Games | 
| The Sims 2: Pets | 2006 | Maxis | EA Games | 
| The Sims 2: Seasons | 2007 | Maxis | EA Games | 
| The Sims 2: University | 2005 | Maxis | EA Games | 
| The Sims 3 | 2009 | Electronic Arts | Electronic Arts | 
| The Sims Castaway Stories | 2008 | EA Games | EA Games | 
| The Sims Life Stories | 2007 | EA Games | EA Games | 
| The Sims Online | 2002 | Maxis | Electronic Arts | 
| The Sims Pet Stories | 2007 | EA Games | EA Games | 
| The Sims | 2000 | Maxis | Electronic Arts | 
| The Sims: Hot Date | 2001 | Maxis | Electronic Arts | 
| The Sims: Livin' Large | 2000 | Maxis | Electronic Arts | 
| SimSafari | 1998 | Electronic Arts, Maxis | Maxis | 
| SimTower | 1994 | OPeNBooK Co., Ltd. | Maxis | 
| SimTown | 1995 | Maxis | Maxis | 
| SimTunes | 1996 | Maxis | Maxis | 
| Sin | 1998 | Ritual Entertainment | Activision | 
| SiN Episodes | 2006 | Ritual Entertainment | Valve Corporation | 
| SiN: Wages of Sin | 1999 | 2015, Inc. | Activision | 
| Singles 2: Triple Trouble | 2005 | Rotobee | Deep Silver | 
| Singles: Flirt Up Your Life | 2004 | Rotobee | Deep Silver | 
| Singularity | 2010 | Raven Software | Activision | 
| Sinking Island | 2007 | White Birds Productions | Microids/Encore Games | 
| Sins of a Solar Empire | 2008 | Ironclad Games | Stardock | 
| Six Days in Fallujah | 2010 | Atomic Games | Atomic Games | 
| Six Feet Under[1] | 1994 | EnQue Software | EnQue Software | 
| Skateboard Park Tycoon | 2001 | Cat Daddy Games | Activision | 
| Ski Park Manager | 2002 | Lankhor | Microids | 
| Ski Resort Extreme | 2004 | Cat Daddy Games | Global Star Software | 
| Ski Resort Tycoon | 2001 | Cat Daddy Games | Activision Value | 
| Ski Resort Tycoon II | 2001 | Cat Daddy Games | Activision Value | 
| SkiFree | 1991 | Chris Pirih | Microsoft | 
| Skyborg: Into the Vortex | 1995 | Fringe Multimedia | SkyBox International | 
| Slave Zero | 1999 | Accolade, Inc. | Atari, Infogrames | 
| Slaves to Armok II: Dwarf Fortress | 2006 | Tarn Adams | Bay 12 Games | 
| Sleepless Night | 2012 | Marcel Weyers | Marcel Weyers | 
| Slide Tap Pop | 2013 | CodeRunners | CodeRunners | 
| Slipstream 5000 | 1995 | The Software Refinery | Gremlin Interactive | 
| Smokin' Guns | 2009 | Smokin' Guns Productions, Iron Claw Interactive |  | 
| Sniper Elite | 2005 | Rebellion Developments | Atari | 
| Sniper: Ghost Warrior | 2010 | City Interactive | City Interactive | 
| Snood | 1996 | David M. Dobson | Snood World | 
| Snoopy vs. the Red Baron | 2006 | Smart Bomb Interactive | Namco Bandai Games America | 
| Snow | 2003 | Studio Mebius | Studio Mebius | 
| Snowcat Simulator | 2014 | United Independent Entertainment | United Independent Entertainment | 
| So Blonde | 2008 | Wizarbox | Eidos Interactive | 
| SODA Off-Road Racing | 1997 | Software Allies | Sierra Entertainment | 
| Solar Crusade | 1996 | Infogrames | Infogrames | 
| Soldat | 2002 | Nick "EnEsCe" Cooper, Michal Marcinkowski |  | 
| Soldier of Fortune | 2000 | Raven Software | Activision | 
| Soldier of Fortune II: Double Helix | 2002 | Raven Software | Activision | 
| Soldier of Fortune: Payback | 2007 | Cauldron HQ | Activision Value | 
| Soldiers at War | 1998 | Random Games | Strategic Simulations, Inc. | 
| Soldiers: Heroes of World War II | 2004 | Best Way | Codemasters | 
| Söldner-X: Himmelsstürmer | 2007 | SideQuest Studios | eastasiasoft | 
| Söldner: Secret Wars | 2004 | Wings Simulations | JoWood Productions | 
| Solein | 2009 | ACID.Games |  | 
| Solid Spheres Deluxe | 2004 | Superior Interactive | Superior Interactive | 
| Sonic & Knuckles Collection | 1997 | Sonic Team | Sega | 
| Sonic 3D Blast | 1996 | Traveller's Tales, Sega | Sega | 
| Sonic Adventure | 1998 | Sonic Team | Sega | 
| Sonic Dreams Collection | 2015 | Arcane Kids | Arcane Kids | 
| Sonic Heroes | 2003 | Sega Studio USA | Sega | 
| Sonic Mega Collection | 2002 | Sonic Team, VR-1 Japan, Inc., Comolink Inc. | Sega | 
| Sonic R | 1997 | Traveller's Tales | Sega | 
| Sonic Riders | 2006 | Sonic Team | Sega | 
| Sonic the Hedgehog CD | 1993 | Sonic Team | Sega | 
| Sonic's Schoolhouse | 1996 | Orion Interactive | Bap Interactive | 
| Sorry! | 1998 | Hasbro Interactive | Third-I Productions | 
| Soul Link | 2004 | Navel | Navel | 
| Soul of the Ultimate Nation | 2007 | Webzen | Webzen, The9, NHN, ijji | 
| Soulbringer | 2000 | Infogrames | Interplay Entertainment | 
| Soul Reaver 2 | 2001 | Crystal Dynamics | Eidos Interactive | 
| SourceForts | 2005 | SourceForts Mod Team |  | 
| South Park | 1998 | Iguana Entertainment | Acclaim Entertainment | 
| South Park: Chef's Luv Shack | 1999 | Acclaim Entertainment | Acclaim Entertainment | 
| Space Ace | 2007 | Digital Leisure Inc. | 1C Company | 
| The Space Bar | 1997 | Boffo Games | Rocket Science Games, SegaSoft | 
| Space Bunnies Must Die! | 1998 | Ripcord Games | Jinx | 
| Space Chimps | 2008 | Wicked Witch Software | Brash Entertainment | 
| Space Colony | 2003 | Firefly Studios | Gathering of Developers | 
| Space Combat | 2004 | Laminar Research | Laminar Research | 
| SpaceChem | 2011 | Zachtronics Industries | Zachtronics Industries | 
| Space Empires III | 1997 | Malfador Machinations | Malfador Machinations | 
| Space Empires IV | 2000 | Malfador Machinations | Shrapnel Games, Strategy First | 
| Space Empires V | 2006 | Malfador Machinations | Strategy First | 
| Space Empires: Starfury | 2003 | Malfador Machinations | Shrapnel Games | 
| Space Giraffe | 2007 | Llamasoft | Llamasoft | 
| Space Girl | 1998 | Realtech VR | Titus Interactive, ANOZOR | 
| Space Hulk: Vengeance of the Blood Angels | 1995 | Key Game | Electronic Arts | 
| Space Invaders X | 2000 | Z-Axis, Ltd. |  | 
| Space Pirates | 2008 | American Laser Games, Inc. | 1C Company | 
| Space Quest 6: Roger Wilco in The Spinal Frontier | 1995 | Sierra Entertainment | Sierra Entertainment | 
| Space Rangers | 2002 | Elemental Games | 1C Company, Micro Application | 
| Space Rangers 2: Dominators | 2004 | Elemental Games | 1C Company | 
| Space Shuttle Mission 2007 | 2008 | Exciting Simulations | Simsquared Ltd. | 
| Space Siege | 2008 | Gas Powered Games | Sega | 
| Spaceward Ho! | 1990 | Delta Tao Software | Delta Tao Software | 
| Spark | 2007 | Code Mallet | Code Mallet | 
| Special Force 2: Tale of the Truthful Pledge | 2007 | Central Internet Bureau | Hezbollah | 
| Special Permit: The Expansion Pack for Cabela's Big Game Hunter | 1998 | HeadGames Publishing | HeadGames Publishing | 
| The Specialists | 2002 | The Specialists mod team |  | 
| Spectre VR | 1993 | Velocity Development | Velocity Development | 
| Spectromancer | 2008 | Apus Software, Three Donkeys LLC | Apus Software, Three Donkeys LLC | 
| Speed Challenge: Jacques Villeneuve's Racing Vision | 2002 | Ubisoft | Ubisoft | 
| Speed Demons | 1999 | EMG | Microids | 
| Speed Devils | 1999 | Ubisoft | Ubisoft | 
| Speedball 2 Tournament | 2007 | Kylotonn | Frogster Interactive Pictures | 
| SpeedRunners | 2013 | DoubleDutch Games | tinyBuild | 
| Spellbound! | 1993 | The Learning Company | The Learning Company | 
| Spellcross | 1998 | Cauldron Ltd. | JRC Interactive | 
| SpellForce: The Order of Dawn | 2003 | Phenomic Game Development | Encore, Inc. | 
| SpellForce: The Breath of Winter | 2004 | Phenomic Game Development | JoWood Productions | 
| SpellForce: Shadow of the Phoenix | 2005 | Phenomic Game Development | JoWood Productions | 
| Spellforce 2: Dragon Storm | 2007 | Phenomic | JoWood Productions | 
| SpellForce 2: Shadow Wars | 2006 | Phenomic | JoWood Productions, Aspyr Media | 
| Spelunky | 2008 | Derek Yu | Independent | 
| Spider-Man | 2000 | Neversoft | Activision | 
| Spider-Man | 2002 | Treyarch, Digital Eclipse Software | Activision | 
| Spider-Man 2 | 2004 | Treyarch, The Fizz Factor, Vicarious Visions, Digital Eclipse, Backbone Entertainment, Aspyr Media | Activision | 
| Spider-Man Cartoon Maker | 1995 | Instinct Corporation | Knowledge Adventure | 
| Spider-Man: Friend or Foe | 2007 | Beenox | Activision | 
| Spider-Man: Web of Shadows | 2008 | Amaze Entertainment | Activision | 
| The Spiderwick Chronicles | 2008 | Stormfront Studios | Sierra Entertainment | 
| Split/Second | 2010 | Black Rock Studio | Disney Interactive Studios | 
| SpongeBob SquarePants Movie | 2004 | AWE Games | THQ | 
| SpongeBob SquarePants: Battle for Bikini Bottom | 2003 | AWE Games, Heavy Iron Studios, Vicarious Visions | THQ | 
| SpongeBob SquarePants: Employee of the Month | 2002 | AWE Games | THQ | 
| SpongeBob SquarePants: Lights, Camera, Pants! | 2005 | AWE Games, THQ Studio Australia, WayForward Technologies | THQ | 
| SpongeBob SquarePants: Operation Krabby Patty | 2001 | AWE Games | THQ | 
| The Spook's Apprentice: The Video Game | 2009 | My Name Is Mircea Inc. | My Name Is Mircea Inc. | 
| Spore | 2008 | Maxis | Electronic Arts | 
| Spore Creature Creator | 2008 | Maxis | Electronic Arts | 
| Spore: Galactic Adventures | 2009 | Maxis | Electronic Arts | 
| Sports Car GT | 1999 | Image Space Incorporated | Electronic Arts | 
| Spring project | 2009 | Swedish Yankspankers |  | 
| Spy Fox in "Dry Cereal" | 1997 | Humongous Entertainment | Atari | 
| Spy Fox 2: "Some Assembly Required" | 1999 | Humongous Entertainment | Atari | 
| Spy Fox 3: "Operation Ozone" | 2001 | Humongous Entertainment | Atari | 
| SpyHunter | 2001 | Paradigm Entertainment, Point of View, Inc., Sidhe Interactive | Midway Games | 
| SpyHunter 2 | 2003 | Angel Studios | Midway Games | 
| Spycraft: The Great Game | 1996 | Activision | Activision | 
| Squeaky Mouse | 1994 | Toru Eguchi | ike | 
| SqueezePlay | 1992 | Henderson Graphics | Henderson Graphics | 
| Stacked with Daniel Negreanu | 2006 | 5000ft | Myelin Media | 
| Stair Dismount | 2002 | Jetro Lauha | tAAt | 
| Stalin vs. Martians | 2009 | Black Wing Foundation | Paradox Interactive | 
| Stalingrad | 2005 | DTF Games | BlackBean Games, 1C Games | 
| Star Defender Series | 2005 | Awem studio | Awem studio | 
| Star General | 1996 | Catware | Strategic Simulations | 
| Star Trek DAC | 2009 | Naked Sky Entertainment, Bad Robot Interactive | Paramount Digital Entertainment | 
| Star Trek Generations | 1997 | Microprose | Microprose | 
| Star Trek Online | 2010 | Cryptic Studios | Atari | 
| Star Trek: Armada | 2000 | Activision, Mad Doc Software | Activision | 
| Star Trek: Armada II | 2001 | Mad Doc Software | Activision | 
| Star Trek: Away Team | 2001 | Reflexive Entertainment | Activision | 
| Star Trek: Bridge Commander | 2002 | Totally Games | Activision | 
| Star Trek: ConQuest Online | 2000 | Genetic Anomalies | Activision Publishing | 
| Star Trek: Deep Space Nine: Dominion Wars | 2001 | Gizmo Games | Simon & Schuster | 
| Star Trek: Deep Space Nine: The Fallen | 2000 | The Collective, Inc. | Simon & Schuster | 
| Star Trek: Elite Force II | 2003 | Ritual Entertainment | Activision | 
| Star Trek: Hidden Evil | 1999 | Presto Studios | Activision | 
| Star Trek: Klingon Academy | 2000 | 14 Degrees East | Interplay Entertainment | 
| Star Trek: Legacy | 2006 | Mad Doc Software | Bethesda Softworks | 
| Star Trek: New Worlds | 2000 | 14 Degrees East | Interplay Entertainment | 
| Star Trek: Starfleet Academy | 1997 | StarFleet Academy Software, Interplay, High Voltage Software | Interplay Entertainment | 
| Star Trek: Starfleet Command | 1999 | Interplay Entertainment | Interplay Entertainment | 
| Star Trek: Starfleet Command II: Empires at War | 2000 | Taldren | Interplay Entertainment | 
| Star Trek: Starfleet Command III | 2002 | Taldren | Activision | 
| Star Trek: Starfleet Command: Orion Pirates | 2001 | Taldren | Interplay Entertainment | 
| Star Trek: Starship Creator | 1998 | Imergy | Simon & Schuster | 
| Star Trek: Starship Creator Warp II | 2000 | Imergy | Simon & Schuster | 
| Star Trek: The Next Generation: Birth of the Federation | 1999 | Microprose | Hasbro | 
| Star Trek: The Next Generation: Klingon Honor Guard | 1998 | MicroProse | MicroProse | 
| Star Trek: Voyager – Elite Force | 2000 | Raven Software | Activision | 
| Star Warped | 1997 | Parroty Interactive | Palladium Interactive | 
| Star Wars Chess | 1993 | Software Toolworks | Software Toolworks | 
| Star Wars Episode I: Racer | 1999 | LucasArts | LucasArts | 
| Star Wars Episode I: The Phantom Menace | 1999 | Big Ape Productions | LucasArts | 
| Star Wars Galaxies | 2003 | Sony Online Entertainment | LucasArts | 
| Star Wars Galaxies: Episode III Rage of the Wookiees | 2005 | Sony Online Entertainment | LucasArts | 
| Star Wars Galaxies: Jump to Lightspeed | 2004 | Sony Online Entertainment | LucasArts | 
| Star Wars Jedi Knight II: Jedi Outcast | 2002 | Raven Software, Vicarious Visions | LucasArts, Activision, Aspyr Media, CyberFront | 
| Star Wars Jedi Knight: Dark Forces II | 1997 | LucasArts | LucasArts | 
| Star Wars Jedi Knight: Jedi Academy | 2003 | Raven Software | LucasArts, Activision | 
| Star Wars Jedi Knight: Mysteries of the Sith | 1998 | LucasArts | LucasArts | 
| Star Wars: Battlefront | 2004 | Pandemic Studios | LucasArts | 
| Star Wars: Battlefront II | 2005 | Pandemic Studios | LucasArts | 
| Star Wars: Behind the Magic | 1998 | LucasArts | LucasArts | 
| Star Wars: Droid Works | 1998 | Lucas Learning | Lucas Learning | 
| Star Wars: Empire at War | 2006 | Petroglyph Games | LucasArts | 
| Star Wars: Empire at War: Forces of Corruption | 2006 | Petroglyph | LucasArts | 
| Star Wars: Episode I: Battle for Naboo | 2000 | Factor 5, LucasArts | LucasArts | 
| Star Wars: Force Commander | 2000 | LucasArts, Ronin Entertainment | LucasArts | 
| Star Wars: Galactic Battlegrounds | 2001 | LucasArts, Ensemble Studios | LucasArts | 
| Star Wars: Knights of the Old Republic | 2003 | BioWare | LucasArts | 
| Star Wars: Knights of the Old Republic II – The Sith Lords | 2004 | Obsidian Entertainment | LucasArts | 
| Star Wars: Rebellion | 1998 | Coolhand Interactive | LucasArts | 
| Star Wars: Republic Commando | 2005 | LucasArts | LucasArts, Activision | 
| Star Wars: Rogue Squadron | 1998 | Factor 5, LucasArts | LucasArts | 
| Star Wars: Shadows of the Empire | 1997 | LucasArts | LucasArts | 
| Star Wars: Starfighter | 2001 | LucasArts | LucasArts | 
| Star Wars: The Clone Wars – Republic Heroes | 2009 | Krome Studios | LucasArts | 
| Star Wars: The Force Unleashed | 2008 | LucasArts | LucasArts | 
| Star Wars: The Old Republic | 2011 | BioWare | LucasArts | 
| Star Wars: TIE Fighter | 2001 | Totally Games | LucasArts | 
| Star Wars: TIE Fighter (Collector's CD-ROM) | 2001 | Totally Games | LucasArts | 
| Star Wars: X-Wing Alliance | 1999 | Totally Games | LucasArts | 
| Star Wars: X-Wing vs. TIE Fighter | 1997 | Totally Games | LucasArts | 
| Star Wars: X-Wing Vs. TIE Fighter - Balance of Power Campaigns | 1997 | Totally Games | LucasArts | 
| Star Wars: X-Wing (Collector's CD-ROM) | 2000 | Totally Games | LucasArts | 
| Star Wars: X-Wing Collector Series | 1998 | Totally Games | LucasArts | 
| Star Wars: X-Wing Trilogy | 2000 | LucasArts | LucasArts | 
| Star Wars: Yoda Stories | 1997 | LucasArts | LucasArts | 
| Star Wolves | 2004 | X-bow Software | 1C Company | 
| StarCraft | 1998 | Blizzard Entertainment | Blizzard Entertainment, Sierra Entertainment | 
| StarCraft: Brood War | 1998 | Saffire, Blizzard Entertainment | Blizzard Entertainment, Sierra Entertainment | 
| StarCraft II: Wings of Liberty | 2010 | Blizzard Entertainment | Blizzard Entertainment | 
| StarCraft II: Heart of the Swarm | 2013 | Blizzard Entertainment | Blizzard Entertainment | 
| Stargate Worlds | 2009 | Cheyenne Mountain Entertainment | FireSky | 
| Starlancer | 2000 | Digital Anvil | Microsoft | 
| StarPeace | 2000 | Oceanus Communications | Monte Cristo Multimedia, Oceanus Communications, Sega, Pugland, SPO Team | 
| Starport: Galactic Empires | 2004 | PlayTechTonics | PlayTechTonics | 
| StarQuest Online | 2007 | Castle Thorn Software LLC | Castle Thorn Software LLC | 
| Stars! | 1995 | Jeff Johnson, Jeff McBride | Empire Interactive | 
| Starscape | 2004 | Moonpod | Moonpod | 
| Starshatter: The Gathering Storm | 2006 | Destroyer Studios | Matrix Games | 
| Starship Titanic | 1998 | The Digital Village | Simon & Schuster Interactive | 
| Starship Troopers | 2005 | Strangelite | Empire Interactive | 
| Starship Troopers: Terran Ascendancy | 2000 | Blue Tongue Entertainment | Microprose | 
| Starsiege | 1999 | Dynamix | Dynamix | 
| Starsky & Hutch | 2003 | Mind's Eye Productions | Empire Interactive | 
| Startopia | 2001 | Mucky Foot Productions | Eidos Interactive | 
| Starwhal: Just the Tip | 2014 | Breakfall | Breakfall | 
| State of Emergency | 2002 | VIS Entertainment | Rockstar Games | 
| State of War | 2001 | Cypron Studios | Crystal Interactive | 
| Stay Tuned for Danger | 1999 | Her Interactive | DreamCatcher | 
| STCC – The Game | 2008 | SimBin Studios | Atari | 
| Steel Panthers III: Brigade Command (1939–1999) | 1997 | Strategic Simulations, Inc. | Strategic Simulations, Inc. | 
| Steel Panthers: World at War | 2000 | Matrix Games | Matrix Games | 
| Steer Madness | 2004 | Veggie Games Inc | Veggie Games Inc | 
| Steins;Gate | 2010 | 5pb. & Nitroplus | 5pb. | 
| Stellar Frontier | 1997 | Drengin.net, SF.net | Drengin.net, SF.net | 
| Stephen King's F13 | 2000 | Presto Studios | Blue Byte Software | 
| Steven Spielberg's Director's Chair | 1996 | Knowledge Adventure | Knowledge Adventure | 
| Still Life | 2005 | Microids | MC2, The Adventure Company | 
| Still Life 2 | 2009 | Gameco Studios | Microids | 
| The Stomping Land | 2014 | Supercrit | Supercrit | 
| Storm: Frontline Nation | 2009 | Colossai Studios | SimBin Studios | 
| Stormrise | 2009 | The Creative Assembly | Sega | 
| Stranger | 2008 | Fireglow Games | Fireglow Games | 
| Stranglehold | 2007 | Midway Chicago | Midway Games | 
| Strategic Command: European Theater | 2002 | Fury Software | Battlefront.com | 
| Strategy Challenges Collection 2: In the Wild | 1997 | Edmark | Edmark, The Learning Company | 
| Street Fighter Alpha | 1995 | Capcom | Capcom | 
| Street Fighter Alpha 2 | 1996 | Capcom | Capcom | 
| Street Fighter IV | 2008 | Dimps, Capcom | Capcom | 
| Street Hacker | 2004 | VirtuWeb Interactive | VirtuWeb Interactive | 
| Street Racing Syndicate | 2004 | Eutechnyx, Streamline Studios | Namco | 
| Streets of SimCity | 1997 | Maxis | Maxis, Electronic Arts | 
| Strike Fighters 2 | 2008 | Third Wire Productions | Third Wire Productions | 
| Strike Fighters 2: Vietnam | 2009 | Third Wire Productions | Third Wire Productions | 
| Strike Fighters: Project 1 | 2002 | Third Wire Productions | Strategy First | 
| Strong Bad's Cool Game for Attractive People | 2008 | Telltale Games | Telltale Games | 
| Stronghold | 2001 | Firefly Studios | Take 2 Interactive, Gathering of Developers | 
| Stronghold 2 | 2005 | Firefly Studios | 2K Games | 
| Stronghold Legends | 2006 | Firefly Studios | 2K Games | 
| Stronghold: Crusader | 2002 | Firefly Studios | Take 2 Interactive and God Games | 
| Stronghold: Crusader Extreme | 2008 | Firefly Studios | Gamecock Media Group | 
| Stubbs the Zombie in Rebel Without a Pulse | 2005 | Wideload Games | Aspyr Media | 
| Stupid Invaders | 2000 | Ubisoft | Xilam | 
| Su-27 Flanker | 1996 | Eagle Dynamics | Strategic Simulations, Inc. | 
| Subarashiki Hibi | 2010 | KeroQ | KeroQ | 
| Submarine TITANS | 2000 | Ellipse Studios | Strategy First | 
| Subterra | 2001 | Crystal Shard | Spiderweb Software | 
| Subterra 2 | 2009 | Crystal Shard | Crystal Shard | 
| Subterranean Animism | 2008 | Team Shanghai Alice | Team Shanghai Alice | 
| Sudeki | 2005 | Climax Group | Microsoft Game Studios | 
| The Suffering | 2004 | Surreal Software | Midway Games | 
| The Suffering: Ties That Bind | 2005 | Surreal Software | Midway Games | 
| Summer Athletics | 2008 | 49Games | Digital Entertainment Pool | 
| Summer Session | 2008 | Hanako Games, Tycoon Games | Hanako Games, Tycoon Games | 
| Summoner | 2000 | Volition, Inc. | THQ | 
| SunAge | 2007 | Vertex4 | Lighthouse Interactive | 
| Super Amazing Wagon Adventure Turbo | 2013 | sparsevector | sparsevector | 
| Super Bubble Pop | 2002 | Zombie Studios | Jaleco | 
| Super Columbine Massacre RPG! | 2005 | Danny Ledonne |  | 
| Super Cosplay War Ultra | 2004 | Team FK | Team FK | 
| Super Match Soccer | 1998 | Cranberry Source | Acclaim Entertainment | 
| Super Meat Boy | 2010 | Team Meat | Team Meat | 
| Super Puzzle Bobble | 2000 | Taito | Acclaim Entertainment, Taito Corporation | 
| Super Puzzle Fighter II Turbo | 2007 | Capcom | Capcom | 
| Superball Arcade | 2003 | Cheeky Monkey Software | Cheeky Monkey Software | 
| Supercar Street Challenge | 2001 | Exakt Entertainment | Activision | 
| SuperPower 2 | 2004 | GolemLabs | DreamCatcher Interactive | 
| Superstars V8 Racing | 2009 | Milestone | Black Bean Games | 
| Supreme Commander | 2007 | Gas Powered Games | THQ | 
| Supreme Commander 2 | 2010 | Gas Powered Games | Square Enix | 
| Supreme Commander: Forged Alliance | 2007 | Gas Powered Games | THQ | 
| Supreme Ruler 2010 | 2005 | BattleGoat Studios | Strategy First | 
| Supreme Ruler 2020 | 2008 | BattleGoat Studios | Paradox Interactive | 
| Supreme Warrior | 1994 | Digital Pictures | Digital Pictures | 
| Surf's Up | 2007 | Ubisoft Quebec City | Ubisoft | 
| Survival Crisis Z | 2004 | Ska Studios | Ska Studios | 
| Survival Project | 2003 | IO Entertainment | Happy Digi, HanbitSoft, et al. | 
| Survival: The Ultimate Challenge | 2001 | Techland Software | Activision Value | 
| Suzuki Alstare Extreme Racing | 1999 | Criterion Games | Ubisoft | 
| Sven Co-op | 1999 | Sven Co-op Team |  | 
| Swarm | 1998 | Reflexive Entertainment | Reflexive Entertainment | 
| SWAT 3: Close Quarters Battle | 1999 | Sierra Northwest | Sierra Entertainment | 
| SWAT 4 | 2005 | Irrational Games | Vivendi Universal Games | 
| Swing | 1997 | Software 2000 | Software 2000 | 
| Switchball | 2007 | Atomic Elbow | Sierra On-Line | 
| Sword of the Stars | 2006 | Kerberos Productions | Paradox Interactive, Lighthouse Interactive | 
| Sword of the Stars: Born of Blood | 2007 | Kerberos Productions | Paradox Interactive, Lighthouse Interactive | 
| Syberia | 2002 | Microids | Microids, 1C Company, The Adventure Company, Typhoon Games | 
| Syberia II | 2004 | MC2-Microids | XS Games, LLC | 
| Syberia III | 2010 | Microids | Microids | 
| Sydney 2000 | 2000 | Attention To Detail | Eidos Interactive | 
| Symbiocom | 1998 | Istvan Pely Productions | Bethesda Softworks | 
| Synthesia | 2008 | Nicholas Piegdon |  | 
| System Shock 2 | 1999 | Irrational Games, Looking Glass Studios | Electronic Arts |