Meglutol

Not to be confused with Miglitol.

Meglutol
Clinical data

ATC code	C10AX05 (WHO)
Identifiers
IUPAC name 3-hydroxy-3-methylpentanedioic acid
CAS Number	503-49-1^N
PubChem (CID)	1662
DrugBank	DB04377^Y
ChemSpider	1600^Y
UNII	CLA99KCD53^Y
KEGG	D04897^Y
ChEBI	CHEBI:16831^Y
ChEMBL	CHEMBL50444^Y
ECHA InfoCard	100.007.247
Chemical and physical data
Formula	C₆H₁₀O₅
Molar mass	162.141 g/mol
3D model (Jmol)	Interactive image
SMILES O=C(O)CC(O)(C)CC(=O)O
InChI InChI=1S/C6H10O5/c1-6(11,2-4(7)8)3-5(9)10/h11H,2-3H2,1H3,(H,7,8)(H,9,10)^Y Key:NPOAOTPXWNWTSH-UHFFFAOYSA-N^Y
^NY (what is this?) (verify)

Meglutol (INN, also known as 3-hydroxy-3-methylglutaric acid, β-hydroxy-β-methylglutaric acid, and dicrotalic acid) is a hypolipidemic agent.

Lipid modifying agents (C10)

GI tract

Cholesterol absorption inhibitors, NPC1L1	Ezetimibe SCH-48461

Bile acid sequestrants/resins (LDL)	Colestyramine Colestipol Colestilan Colextran Colesevelam

Liver

Statins (HMG-CoA reductase, LDL)	Simvastatin^# Atorvastatin Fluvastatin Lovastatin Mevastatin Pitavastatin Pravastatin Rosuvastatin Cerivastatin^‡

Niacin and derivatives (HDL and LDL)	Niceritrol Niacin Nicofuranose Aluminium nicotinate Nicotinyl alcohol Acipimox

MTTP inhibitors (VLDL)	Dirlotapide Lomitapide Mitratapide

Blood vessels

Fibrates (PPAR)	Clofibrate^‡ Bezafibrate Aluminium clofibrate Gemfibrozil Fenofibrate Simfibrate Ronifibrate Ciprofibrate Etofibrate Clofibride Clinofibrate

CETP inhibitors (HDL)	Anacetrapib^† Dalcetrapib^§ Evacetrapib^§ Torcetrapib^§

Combinations

Other

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

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