Zofenopril

Zofenopril
Clinical data

AHFS/Drugs.com	International Drug Names
Routes of administration	Oral
ATC code	C09AA15 (WHO)
Identifiers
IUPAC name (2S,4S)-1-[(2S)-3-benzoylsulfanyl-2-methylpropanoyl]-4-phenylsulfanylpyrrolidine-2-carboxylic acid
CAS Number	81872-10-8^Y
PubChem (CID)	92400
IUPHAR/BPS	6462
ChemSpider	83422^N
UNII	290ZY759PI^N
KEGG	D08688^Y
ChEBI	CHEBI:78539^N
ChEMBL	CHEMBL331378^N
Chemical and physical data
Formula	C₂₂H₂₃NO₄S₂
Molar mass	429.552 g/mol
3D model (Jmol)	Interactive image
SMILES O=C(N2[C@H](C(=O)O)C[C@H](Sc1ccccc1)C2)[C@H](C)CSC(=O)c3ccccc3
InChI InChI=1S/C22H23NO4S2/c1-15(14-28-22(27)16-8-4-2-5-9-16)20(24)23-13-18(12-19(23)21(25)26)29-17-10-6-3-7-11-17/h2-11,15,18-19H,12-14H2,1H3,(H,25,26)/t15-,18+,19+/m1/s1^N Key:IAIDUHCBNLFXEF-MNEFBYGVSA-N^N
^NY (what is this?) (verify)

Zofenopril (INN) is a medication that protects the heart and helps reduce high blood pressure. It is an angiotensin-converting enzyme (ACE) inhibitor.^[1]

In small studies, zofenopril appeared significantly more effective in reducing hypertension than two older antihypertensive drugs, atenolol and enalapril, and was associated with fewer adverse effects.^[2]^[3]

Zofenoprilat — the active metabolite of zofenopril

References

↑ Ambrosioni E (2007). "Defining the role of zofenopril in the management of hypertension and ischemic heart disorders". Am J Cardiovasc Drugs. 7 (1): 17–24. doi:10.2165/00129784-200707010-00002. PMID 17355163.
↑ Nilsson P (October 2007). "Antihypertensive efficacy of zofenopril compared with atenolol in patients with mild to moderate hypertension". Blood Press Suppl. 2: 25–30. PMID 18046976.
↑ Mallion JM (October 2007). "An evaluation of the initial and long-term antihypertensive efficacy of zofenopril compared with enalapril in mild to moderate hypertension". Blood Press Suppl. 2: 13–8. PMID 18046974.

Antihypertensives: agents acting on the renin–angiotensin system (C09)

ACE inhibitors ("-pril")	Sulfhydryl-containing: Captopril Rentiapril Zofenopril Dicarboxylate-containing: Enalapril^# Benazepril Cilazapril Delapril Imidapril Lisinopril (+HCT) Moexipril Perindopril (+indapamide) Quinapril (+HCT) Ramipril Spirapril Temocapril Trandolapril Phosphonate-containing: Fosinopril (+HCT) Other/ungrouped: Alacepril

AIIRAs ("-sartan")	Azilsartan Candesartan Eprosartan Fimasartan Irbesartan Losartan (+HCT) Olmesartan (+amlodipine) Tasosartan^§ Telmisartan (+HCT) Valsartan (+HCT, +amlodipine, +sacubitril)

Renin inhibitors ("-kiren")	Aliskiren (+amlodipine, +amlodipine and HCT) Remikiren^§

^#WHO-EM ^‡Withdrawn from market Clinical trials: ^†Phase III ^§Never to phase III

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